Journal
INFLAMMATORY BOWEL DISEASES
Volume 17, Issue 1, Pages 396-409Publisher
OXFORD UNIV PRESS INC
DOI: 10.1002/ibd.21354
Keywords
colorectal cancer; inflammatory bowel disease; intestinal microbiota
Categories
Funding
- National Institutes of Health (NIH) [DK047700, DK073338, DK007737]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [T32DK007737, R56DK047700, R01DK047700, R01DK073338] Funding Source: NIH RePORTER
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Recently, an unprecedented effort has been directed at understanding the interplay between chronic inflammation and development of cancer, with the case of inflammatory bowel disease (IBD)-associated colorectal cancer at the forefront of this research endeavor. The last decade has been particularly fertile, with the discovery of numerous innovative paradigms linking various inflammatory, proliferative, and innate and adaptive immune signaling pathways to the development of colorectal cancer. Because of the preponderant role of the intestinal microbiota in the initiation and progression of IBD, recent efforts have been directed at understanding the relationship between bacteria and colorectal cancer. The microbiota and its collective genome, the microbiome, form a diverse and complex ecological community that profoundly impacts intestinal homeostasis and disease states. This review will discuss the differential influence of the microbiota on the development of IBD-associated colorectal cancer and highlight the role of innate immune sensor-dependent as well as -independent mechanisms in this pathology.
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