Journal
INFLAMMATION
Volume 38, Issue 1, Pages 218-223Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-014-0025-9
Keywords
asymmetric dimethylarginine; systemic sclerosis; nitric oxide; arginine
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Funding
- Key Project of the Education Department of Anhui Province Natural Science Research [KJ2012A165, KJ2014A127]
- Anhui Provincial Natural Science Foundation [1308085MH169]
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Systemic sclerosis (SSc) is a kind of autoimmune disease characterized by inflammatory and endothelial dysfunction. Asymmetric dimethylarginine (ADMA), as an endogenous nitric oxide synthase inhibitor, can cause or contribute to the inflammatory syndrome and endothelial dysfunction. Recently, increased ADMA levels have been demonstrated in SSc, revealing that ADMA might play an important role for the associated manifestations of SSc. Besides, ADMA may play a significant role in the level of NO, which is produced by arginine. In the review, we discuss the role of arginine and ADMA in patients with SSc.
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