Journal
INFLAMMATION
Volume 37, Issue 5, Pages 1779-1788Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-014-9908-z
Keywords
heme oxygenase-1; carbon monoxide; autoimmune diseases; anti-inflammation; immunomodulation
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Funding
- National Natural Science Foundation of China [81102192, 81373073]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20113420120008]
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Heme oxygenase-1 (HO-1), the inducible isoform of heme oxygenase (HO), has raised a lot of concerns in recent years due to its multiple functions. HO-1 was found to be a pivotal cytoprotective, antioxidant, anti-apoptotic, immunosuppressive, as well as anti-inflammatory molecule. Recent studies have clarified its significant functions in many diseases with substantial findings. In autoimmune diseases, HO-1 may have promising therapeutic potential. Here, we briefly reviewed recent advances in this field, aiming at hopefully exploring the potential therapeutic roles of HO-1, and design HO-1-based strategies for the treatment of autoimmune diseases.
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