Journal
INFLAMMATION
Volume 37, Issue 4, Pages 1091-1101Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-014-9833-1
Keywords
carvacrol; acute lung injury; LPS; NF-kappa B; MAPK
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Carvacrol, the major component of Plectranthus amboinicus, has been known to exhibit anti-inflammatory activities. The aim of this study was to investigate the effects of carvacrol on lipopolysaccharide (LPS)-induced endotoxemia and acute lung injury (ALI) in mice. Mice were injected intraperitoneally (i.p.) with LPS and the mortality of mice for 7 days were observed twice a day. Meanwhile, the protective effect of carvacrol (20, 40 or 80 mg/kg) on LPS-induced endotoxemia were detected. Using an experimental model of LPS-induced ALI, we examined the effect of carvacrol in resolving lung injury. The results showed that carvacrol could improve survival during lethal endotoxemia and attenuate LPS-induced ALI in mice. The anti-inflammatory mechanisms of carvacrol may be due to its ability to inhibit NF-kappa B and MAPKs signaling pathways, thereby inhibiting inflammatory cytokines TNF-alpha, IL-6 and IL-1 beta production.
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