Journal
INFLAMMATION
Volume 35, Issue 4, Pages 1525-1529Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10753-012-9467-0
Keywords
MiR-146a; autoimmunity; autoimmune diseases
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Funding
- National Natural Science Foundation of China [30830089, 81172764]
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MicroRNAs (miRNAs) are a group of approximately 20-22-nucleotide-long non-coding RNAs that repress target gene expression through mRNA degradation and translation inhibition. MiRNA (miR)-146a, located in the second exon of the LOC285628 gene on human chromosome 5, is a negative regulator in immune and inflammatory responses. Studies have indicated that miR-146a is associated with the pathogenesis of several autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and Sjogren's syndrome. In this review, emphasis will be laid on the recent progress in the functional roles of miR-146a in these autoimmune diseases.
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