Journal
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA
Volume 28, Issue 3, Pages 371-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.idc.2014.06.001
Keywords
HIV; Antiretroviral therapy; Nucleoside/nucleotide reverse transcriptase inhibitors; Non-nucleoside reverse transcriptase inhibitors; Protease inhibitors; Integrase strand transfer inhibitors; Fusion inhibitor; CCR5 antagonist
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The rapid advances in drug discovery and the development of antiretroviral therapy is unprecedented in the history of modern medicine. The administration of chronic combination antiretroviral therapy targeting different stages of the human immunodeficiency virus' replicative life cycle allows for durable and maximal suppression of plasma viremia. This suppression has resulted in dramatic improvement of patient survival. This article reviews the history of antiretroviral drug development and discusses the clinical pharmacology, efficacy, and toxicities of the antiretroviral agents most commonly used in clinical practice to date.
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