Journal
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA
Volume 23, Issue 4, Pages 817-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.idc.2009.06.002
Keywords
Drug resistance; Methicillin-resistant Staphylococcus aureus; Vancomycin-resistant Enterococcus; Vancomycin intermediate-susceptible Staphylococcus aureus; Extended-spectrum beta-lactamase; Penicillin-resistant Streptococcus pneumoniae; Klebsiella pneumoniae carbapenemase; Acinetobacter baumanii
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Resistance to antimicrobial drugs is increasing at an alarming rate among both gram-positive and gram-negative bacteria. Traditionally, bacteria resistant to multiple antimicrobial agents have been restricted to the nosocomial environment. A disturbing trend has been the recent emergence and spread of resistant pathogens in nursing homes, in the community, and in the hospital. This article reviews the epidemiology, molecular mechanisms of resistance, and treatment options for pathogens resistant to antimicrobial drugs.
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