Journal
INFECTION GENETICS AND EVOLUTION
Volume 21, Issue -, Pages 616-626Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.meegid.2013.11.016
Keywords
Staphylococcus; Regulatory RNA; Virulence
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Funding
- Centre National de la Recherche Scientifique (CNRS, PR)
- Agence Nationale de la Recherche and the Laboratoires d'excellence (LABEX) NetRNA [ANR-10-LABX-36]
- National Health and Medical Research Council (NHMRC), Australia
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RNA molecules with regulatory functions in pathogenic bacteria have benefited from a renewed interest these two last decades. In Staphylococcus aureus, recent genome-wide approaches have led to the discovery that almost 10-20% of genes code for RNAs with critical regulatory roles in adaptive processes. These RNAs include trans-acting RNAs, which mostly act through binding to target mRNAs, and cis-acting RNAs, which include regulatory regions of mRNAs responding to various metabolic signals. Besides recent analysis of S. aureus transcriptome has revealed an unprecedented existence of pervasive transcription generating a high number of weakly expressed antisense RNAs along the genome as well as numerous mRNAs with overlapped regions. Here, we will illustrate the diversity of trans-acting RNAs and illustrate how they are integrated into complex regulatory circuits, which link metabolism, stress response and virulence. (C) 2013 Elsevier B.V. All rights reserved.
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