Journal
INFECTION GENETICS AND EVOLUTION
Volume 28, Issue -, Pages 11-14Publisher
ELSEVIER
DOI: 10.1016/j.meegid.2014.08.026
Keywords
Human bocavirus; Complete genome; Virus evolution; Recombination
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Funding
- Russian Foundation for Basic Research [13-04-00554a]
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Whole genome sequencing of Novosibirsk human bocavirus (HBoV) isolates has detected an isolate that emerged via recombination between HBoV3 and HBoV4 genotypes. The recombination site is located between regions with abnormally low and abnormally high GC contents in the genome. This site is a bocavirus recombination hotspot and coincides with one of two parvovirus recombination hotspots. The Novosibirsk recombinant isolate, which is similar to a previously studied isolate from Thailand, utilizes the strategy of borrowing ORF3, which encodes structural proteins, of a rare genotype HBoV4. The role of recombination in HBoV evolution is discussed. (C) 2014 Elsevier B.V. All rights reserved.
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