Journal
INFECTION GENETICS AND EVOLUTION
Volume 16, Issue -, Pages 38-53Publisher
ELSEVIER
DOI: 10.1016/j.meegid.2013.01.009
Keywords
Multi-locus sequence typing (MLST); Next-generation sequence data; Molecular epidemiology; Pathogen evolution
Categories
Funding
- CIBIO (Portugal)
- George Washington University
- Fundacion Caja Madrid, Spain
- Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT), Gobierno de Chile, Becas
- BYU Graduate Mentoring
- Research Awards
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Multi-locus sequence typing (MLST) is a high-resolution genetic typing approach to identify species and strains of pathogens impacting human health, agriculture (animals and plants), and biosafety. In this review, we outline the general concepts behind MLST, molecular approaches for obtaining MIST data, analytical approaches for MLST data, and the contributions MLST studies have made in a wide variety of areas. We then look at the future of MLST and their relative strengths and weaknesses with respect to whole genome sequence typing approaches that are moving into the research arena at an ever-increasing pace. Throughout the paper, we provide exemplar references of these various aspects of MLST. The literature is simply too vast to make this review comprehensive, nevertheless, we have attempted to include enough references in a variety of key areas to introduce the reader to the broad applications and complications of MLST data. (C) 2013 Elsevier B.V. All rights reserved.
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