Journal
INFECTION GENETICS AND EVOLUTION
Volume 20, Issue -, Pages 118-123Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.meegid.2013.08.016
Keywords
Hantavirus; Crocidura; Shrew; Phylogeny; Guinea
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Funding
- U.S. Public Health Service [R01AI075057]
- National Institute of Allergy and Infectious Diseases [P20GM103516]
- National Institute of General Medical Sciences, National Institutes of Health
- Ministere de l'environnement et du developpement durable, Republique de Guinee [0003394, 0003329, 0003374]
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Elucidation of the molecular phylogeny of shrew-borne hantaviruses in sub-Saharan Africa has been hampered by the lack of full-length viral genomes. In this report, we present the complete genome analysis of a newfound hantavirus, designated Bow, virus, detected in ethanol-fixed intercostal muscle of a Doucet's musk shrew (Crocidura douceti), captured in southwestern Guinea in February 2012. Full-length amino acid sequence comparison of the S-, M-and L-segment gene products revealed that Bow, virus differed by 24.1-53.4%, 17.0-59.9% and 14.6-39.7%, respectively, from all other representative rodent-, shrew-and mole-borne hantaviruses. Phylogenetic analysis, using maximum-likelihood and Bayesian methods, under the GTR + Iota + Gamma model of evolution, showed that Bowe virus shared a common ancestry with Tanganya virus, a hantavirus detected in the Therese's shrew (Crocidura theresae) in Guinea. Whole genome analysis of many more hantaviruses from sub-Saharan Africa are needed to better clarify how the radiation of African shrews might have contributed to the phylogeography of hantaviruses. (C) 2013 Elsevier B.V. All rights reserved.
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