Journal
INFECTION GENETICS AND EVOLUTION
Volume 12, Issue 5, Pages 883-893Publisher
ELSEVIER
DOI: 10.1016/j.meegid.2012.02.008
Keywords
beta-Lactamases; Integron; Transposon; Insertion sequence; ESBL
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Genes encoding extended-spectrum beta-lactamases (ESBLs) have been reported in a variety of Gram-negative species, mostly in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii. They are either TEM- or SHV-derivatives, CTX-M-like enzymes and less frequently of the GES, PER, or VEB types. The mechanisms at the origin of their acquisition are diverse, and mostly are related to insertion sequences, transposons and class 1 integrons. This diversity of genetic vehicles at the origin of these mobilization/acquisition processes may explain spread of ESBLs worldwide. (C) 2012 Elsevier B.V. All rights reserved.
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