Journal
INFECTION GENETICS AND EVOLUTION
Volume 10, Issue 7, Pages 919-924Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.meegid.2010.05.014
Keywords
Group I coronavirus; nsp1; Innate immunity
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Funding
- Fundamental Research Funds for the Central Universities [0904010]
- Shanghai Municipal Science and Technology Commission [07DZ22940]
- Shanghai Municipal Wildlife Administration [SBHZ2006_01]
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The nsp1 protein of the highly pathogenic SARS coronavirus suppresses host protein synthesis, including genes involved in the innate immune system. A bioinformatic analysis revealed that the nsp1 proteins of group I and SARS coronaviruses have similar structures. Nsp1 proteins of group I coronaviruses interacted with host ribosomal 40S subunit and did not inhibit IRF-3 activation. However, synthesis of host immune and non-immune proteins was inhibited by nsp1 proteins at both transcriptional and translational levels, similar to SARS coronavirus nsp1. These results indicate that different coronaviruses might employ the same nsp1 mechanism to antagonize host innate immunity and cell proliferation. However, nsp1 may not be the key determinant of viral pathogenicity, or the factor used by the SARS coronavirus to evade host innate immunity. (C) 2010 Elsevier B.V. All rights reserved.
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