Journal
INFECTION GENETICS AND EVOLUTION
Volume 9, Issue 4, Pages 581-593Publisher
ELSEVIER
DOI: 10.1016/j.meegid.2009.03.002
Keywords
Streptococcus; Group A streptococcus; Streptococcus pyogenes; Population biology; Population genetics; Epidemiology; Ecology; Evolution
Categories
Funding
- National Institutes of Health [GM060793, AI053826, AI061454, AI065572]
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Streptococcus pyogenes, also referred to as beta-hemolytic group A streptococci, are strictly human pathogens with a global distribution and high prevalence of infection. The organisms are characterized by high levels of genetic recombination, extensive strain diversity, and a narrow habitat. This review highlights many key features of the population genetics and molecular epidemiology of this biologically diverse bacterial species, with special emphasis on ecological subdivisions and tissue-specific infections, strain diversity and population dynamics in communities, selection pressures arising from the specific host immune response and antibiotic exposure, and within-host selection during the course of invasive disease. (C) 2009 Elsevier B.V. All rights reserved.
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