Journal
INFECTION AND IMMUNITY
Volume 81, Issue 3, Pages 723-732Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.00969-12
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Funding
- Wellcome Trust [098051, 076964]
- MRC [MR/J006874/1] Funding Source: UKRI
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MicroRNAs (miRNAs) are small noncoding molecules that control gene expression posttranscriptionally, with microRNA-155 (miR-155) one of the first to be implicated in immune regulation. Here, we show that miR-155-deficient mice are less able to eradicate a mucosal Citrobacter rodentium infection than wild-type C57BL/6 mice. miR-155-deficient mice exhibited prolonged colonization associated with a higher C. rodentium burden in gastrointestinal tissue and spread into systemic tissues. Germinal center formation and humoral immune responses against C. rodentium were severely impaired in infected miR-155-deficient mice. A similarly susceptible phenotype was observed in mu MT mice reconstituted with miR-155-deficient B cells, indicating that miR-155 is required intrinsically for mediating protection against this predominantly luminal bacterial pathogen.
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