Journal
INFECTION AND IMMUNITY
Volume 77, Issue 5, Pages 2184-2192Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.01455-08
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Funding
- Health Manpower Development Plan (HMDP) Fellowship, Ministry of Health, Singapore
- International Fellowship, Agency for Science, Technology and Research (A*STAR)/National Medical Research Council (NMRC), Singapore
- Netherlands Organization for Scientific Research
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Toll-like receptor (TLR)-based signaling pathways in the host may be modulated by pathogens during the course of infection. We describe a novel immunomodulatory mechanism in which Aspergillus fumigatus conidia induce attenuation of TLR2- and TLR4-mediated interleukin (IL)-6 and IL-1 beta proinflammatory responses in human mononuclear cells with suppression of IL-1 beta mRNA transcription. Background TLR2 and TLR4 mRNA transcription was not influenced. A. fumigatus conidia induced TLR2 internalization and uptake into the phagosome with a resultant decrease in surface receptor expression. A. fumigatus hyphae, on the other hand, selectively downregulated the TLR4-mediated response. These novel immunosuppressive effects may facilitate the invasiveness of A. fumigatus.
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