Antiinflammatory and antiulcerogenic activities of Pistacia lentiscus L. leaves extracts

Plants have been used for centuries in traditional medicines. In the present study, we investigated in vivo the efficacy of the aqueous and organic extracts from Pistacia lentiscus L leaves for their anti-inflammatory and antiulcerogenic activities using the carrageenan-induced paw edema assay and HCl/ethanol-induced Gastric lesions in rats, respectively. The aqueous (AQ), chloroformic (CHCl3), ethyl acetate (EtOAc) and methanolic (MeOH) leaves extracts (50,100 and 200 mg/kg) given intraperitoneally (i.p.) showed a dose-dependent anti-inflammatory effect. The CHCl3, EtOAc and MeOH leaves extracts when administered orally (p.o), (25,50 and 100 mg/kg), exhibited an inhibition of gastric lesions in a concentration-related manner. The effect of all extracts in both activities were compared with reference drugs. (C) 2013 Elsevier B.V. All rights reserved.