Journal
INDUSTRIAL CROPS AND PRODUCTS
Volume 42, Issue -, Pages 520-526Publisher
ELSEVIER
DOI: 10.1016/j.indcrop.2012.06.045
Keywords
Podophyllotoxin; Acyloxy; E-ring modification; Semisynthesis; Insecticidal activity
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Funding
- National Natural Science Foundation of China [31071737]
- Fok Ying Tong Education Foundation for Young Talents [121032]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1035]
- Special Funds of Central Colleges Basic Scientific Research Operating Expenses [QN2009045]
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In continuation of our program aimed at the discovery and development of natural products-based insecticidal agents, a series of novel phenazine derivatives of 4 beta-acyloxypodophyllotoxin modified in the E-ring were synthesized, and preliminarily evaluated for their insecticidal activity against the pre-third-instar larvae of Mythimna separata Walker in vivo. Among all the derivatives, compounds 7b, 7g, 7h and 7j exhibited more pronounced insecticidal activity than or comparable to toosendanin. Especially compounds 7h and 7j displayed the best promising insecticidal activity. Meanwhile, the relationships between their structures and the insecticidal activity were also described. (C) 2012 Elsevier B.V. All rights reserved.
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