Journal
MAYO CLINIC PROCEEDINGS
Volume 90, Issue 8, Pages 1135-1151Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mayocp.2015.06.010
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Funding
- National Institutes of Health/National Institute of Neurological Disorders and Stroke [R01 NS072205, P01 NS045685]
- National Institutes of Health/National Institute of Dental and Craniofacial Research [U01 DE017018]
- National Vulvodynia Association (NVA)
- UNC NCTraCS [50KR81417]
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Drugs that target G protein-coupled receptors (GPCRs) represent the primary treatment strategy for patients with acute and chronic pain; however, there is substantial individual variability in both the efficacy and adverse effects associated with these drugs. Variability in drug responses is due, in part, to individuals' diversity in alternative splicing of pain-relevant GPCRs. G protein-coupled receptor alternative splice variants often exhibit distinct tissue distribution patterns, drug-binding properties, and signaling characteristics that may impact disease pathology as well as the extent and direction of analgesic effects. We review the importance of GPCRs and their known splice variants to the management of pain. (C) 2015 Mayo Foundation for Medical Education and Research
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