Journal
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
Volume 49, Issue 16, Pages 7323-7329Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ie100389v
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Funding
- University Grants Commission (UGC), New Delhi, India
- CSIR, New Delhi, India [21(0760)/09/EMR-II]
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A novel type of pH-sensitive hydrogel blend of poly(vinyl alcohol) with acrylic acid-graft-guar gum has been prepared. Microspheres with a size of similar to 10 mu m were produced by the water-in-oil (w/o) emulsification method for investigating the controlled release of an antituberculosis drug, isoniazid. These novel carriers were analyzed for surface morphology, size, effect of pH, swelling, drug loading, and in vitro release of isoniazid in pH 1.2 and 7.4 media. The kinetics of drug release was analyzed using empirical equations. Release times of the drug were increased to 8 h from its nascent plasma half-life of 0.5-1.6 h.
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