Journal
MATRIX BIOLOGY
Volume 42, Issue -, Pages 11-55Publisher
ELSEVIER
DOI: 10.1016/j.matbio.2015.02.003
Keywords
Proteoglycan; Glycosaminoglycan; Cancer growth; Angiogenesis; Growth factor modulation
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Funding
- National Institutes of Health [RO1 CA39481, RO1 CA47282, RO1 CA164462]
- German Research Council [SFB 815, SFB 1039]
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We provide a comprehensive classification of the proteoglycan gene families and respective protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores. These three signatures were utilized to design four major classes of proteoglycans with distinct forms and functions: the intracellular, cell-surface, pericellular and extracellular proteoglycans. The proposed nomenclature encompasses forty-three distinct proteoglycan-encoding genes and many alternatively-spliced variants. The biological functions of these four proteoglycan families are critically assessed in development, cancer and angiogenesis, and in various acquired and genetic diseases where their expression is aberrant. (C) 2015 Published by Elsevier B.V.
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