Journal
MATRIX BIOLOGY
Volume 44-46, Issue -, Pages 207-223Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matbio.2015.03.004
Keywords
MMP; MT-MMP; Transmembrane; GPI-anchor; ECM degradation
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Funding
- Arthritis Research UK [19797]
- Medical Research Council [G0802007] Funding Source: researchfish
- Versus Arthritis [19797] Funding Source: researchfish
- MRC [G0802007] Funding Source: UKRI
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Membrane-type matrix metalloproteinases (MT-MMPs) form a subgroup of the matrix metalloproteinase (MMP) family, and there are 6 MT-MMPs in humans. MT-MMPs are further sub-classified into type I transmembrane-type (MT1, -MT2-, MT3- and MT5-MMPs) and glycosylphosphatidylinositol (GPI)-anchored type (MT4- and MT6-MMPs). In either case MT-MMPs are tethered to the plasma membrane, and this cell surface expression provides those enzymes with unique functionalities affecting various cellular behaviours. Among the 6 MT-MMPs, MT1-MMP is the most investigated enzyme and many of its roles and regulations have been revealed to date, but the potential roles and regulatory mechanisms of other MT-MMPs are gradually getting clearer as well. Further investigations of MT-MMPs are likely to reveal novel pathophysiological mechanisms and potential therapeutic strategies for different diseases in the future. (C) 2015 Elsevier B.V. All rights reserved.
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