Journal
MATRIX BIOLOGY
Volume 43, Issue -, Pages 15-26Publisher
ELSEVIER
DOI: 10.1016/j.matbio.2015.01.023
Keywords
Angiogenesis; Extracellular matrix; Proteoglycan; Decorin; Mechanism; Therapy
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Funding
- Medical Research Fund of Turku University Hospital
- Cancer Foundation of South-Western Finland
- Turku University Foundation Fund of Turku University
- Finnish Foundation for Cardiovascular Research
- National Institutes of Health [R01 HL064387, EB 012558]
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Angiogenesis, the formation of new blood vessels from preexisting vessels, is a highly complex process. It is regulated in a finely-tuned manner by numerous molecules including not only soluble growth factors such as vascular endothelial growth factor and several other growth factors, but also a diverse set of insoluble molecules, particularly collagenous and non-collagenous matrix constituents. In this review we have focused on the role and potential mechanisms of a multifunctional small leucine-rich proteoglycan decorin in angiogenesis. Depending on the cellular and molecular microenvironment where angiogenesis occurs, decorin can exhibit either a proangiogenic or an antiangiogenic activity. Nevertheless, in tumorigenesis-associated angiogenesis and in various inflammatory processes, particularly foreign body reactions and scarring, decorin exhibits an antiangiogenic activity, thus providing a potential basis for the development of decorin-based therapies in these pathological situations. (C) 2015 Elsevier B.V. All rights reserved.
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