Journal
INDIAN PEDIATRICS
Volume 49, Issue 1, Pages 35-41Publisher
SPRINGER INDIA
DOI: 10.1007/s13312-012-0012-x
Keywords
Clofibrate; Jaundice; Management; Meta-analysis; Newborn; Phototherapy
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Funding
- National Natural Science Foundation of China [31171020, 30825039, 30973236]
- Ministry of Education of China [IRT0935, 20070610092]
- Science and Technology Department of Sichuan Province [2010SZ0280]
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Objective: To evaluate the effect of clofibrate for unconjugated hyperbilirubinemia in neonates. Methods:A systematic review with meta-analysis of randomized controlled trials or quasi-randomized controlled trials was conducted to evaluate the clofibrate treatment in neonates with unconjugated hyperbilirubinemia. We followed the guidelines from the Cochrane review group and the PRISMA statement. Results:Of 148 studies identified, a total of 13 studies on 867 infants were included. A single oral administration of clofibrate was associated with decreased need of phototherapy (RR:.38, 95% CI: 0.21 to 0.68), shortened duration of phototherapy (mean duration: 23.88 h, 95% CI: 33.03 to -14.72 h) and reduced peak total serum bilirubin (mean duration: -1.62 mg/dL, 95% CI: 2.13 to -1.11 mg/dL). These effects were especially obvious in term infants and infants without hemolytic diseases. Data regarding mortality or kernicterus were not available from included studies. Conclusions:Clofibrate may have short-term benefits for the infants with hyperbilirubinaemia, especially for population of term infants and infants without hemolytic diseases. Large RCTs with long-term followup are required to verify the safety of clofibrate and assess its long-term effects.
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