Journal
INDIAN JOURNAL OF PHARMACOLOGY
Volume 46, Issue 6, Pages 579-583Publisher
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/0253-7613.144891
Keywords
Cancer; endocan; endothelial cell-specific molecule; proteoglycan
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Endocan is a novel endothelium derived soluble dermatan sulfate proteoglycan. It has the property of binding to a wide range of bioactive molecules associated with cellular signaling and adhesion and thus regulating proliferation, differentiation, migration, and adhesion of different cell types in health and disease. An increase in tissue expression or serum level of endocan reflects endothelial activation and neovascularization which are prominent pathophysiological changes associated with inflammation and tumor progression. Consequently, endocan has been used as a blood-based and tissue-based biomarker for various cancers and inflammation and has shown promising results.
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