Journal
INDIAN JOURNAL OF OPHTHALMOLOGY
Volume 58, Issue 1, Pages 76-78Publisher
ALL INDIA OPHTHALMOLOGICAL SOC
DOI: 10.4103/0301-4738.58480
Keywords
Coats disease; vascular endothelial growth factor
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We describe the role of intravitreal anti-vascular endothelial growth factor (VEGF) agents in Coats disease in children. In a prospective, interventional, non-randomized case series, three patients (three eyes) aged 16, seven and two years were diagnosed to have Coats disease. In Case 1 (16 yr/ male) with macular edema, previous laser photocoagulation being unsuccessful, intravitreal pegaptanib sodium (Macugen) was tried. Case 2 (seven yr/ male) and Case 3 (two yr/ female) were diagnosed to have Stage 4 Coats and underwent external needle drainage, laser photocoagulation, SF6 gas injection and intravitreal injection of bevacizumab (Avastin). Reduction of exudation and attached posterior pole (Cases 2 and 3) was seen at a follow-up of six months and two months respectively. Intravitreal anti-VEGF agents may be successfully used as adjunct treatment in select cases of Coats disease in childhood.
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