Journal
INDIAN JOURNAL OF MICROBIOLOGY
Volume 53, Issue 2, Pages 175-180Publisher
SPRINGER
DOI: 10.1007/s12088-013-0362-7
Keywords
Chaetomium globosum; Antifungal activity; Chaetoglobosins
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Funding
- National Natural Science Foundation of China [31271991]
- ministry of education doctoral program funds [20120061110082]
- Ministry of Agriculture Public Benefit Industry of the People's Republic of China [20113016]
- project of National Key Technology R&D Program in the 12th Five year Plan of China [2012BAD19B04]
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The fungal endophyte Chaetomium globosum No.04 was isolated from the medicinal plant Ginkgo biloba. The crude extract of the fungus fermentation were active in the agar-diffusion tests against the phytopathogenic fungi Rhizopus stolonifer and Coniothyrium diplodiella. Further bioassay-guided chemical investigation led to the isolation and purification of six alkaloids and three non-targeted compounds from 50 L fermentation of this endophytic fungus and their structures were elucidated as chaetoglobosin A, C, D, E, G, R (1-6), ergosterol, allantoin and uracil, by means of spectroscopic analysis. Compounds 1-6 showed significant growth inhibitory activity against R. stolonifer and C. diplodiella at a concentration of 20 mu g/disc. We present here, for the first time, the potent antifungal activity of chaetoglobosins from endophytic fungi against two important phytopathogenic fungi R. stolonifer and C. diplodiella.
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