Journal
INDIAN JOURNAL OF MEDICAL MICROBIOLOGY
Volume 29, Issue 1, Pages 60-62Publisher
ELSEVIER
DOI: 10.4103/0255-0857.76527
Keywords
Linezolid resistance; Staphylococcus cohnii; Staphylococcus kloosii
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Linezolid, a viable alternative to vancomycin against methicillin resistant staphylococcal isolates, has been in use for a decade around the globe. However, resistance against staphylococci remains extremely rare and unreported from most of the Asian countries. Herein, we report two cases of linezolid resistant, coagulase negative staphylococcal sepsis for the first time from India. The first case was an 18-year-old burn patient, who, after a major graft surgery, landed in sepsis, and linezolid resistant Staphylococcus cohnii with an minimum inhibitory concentration (MIC) of > 256 mu g/ml by both broth microdilution and Etest, was isolated from multiple blood cultures. The second patient was a 60-year-old male with an intracranial bleed and sepsis, from whose blood cultures, linezolid resistant Staphylococcus kloosii was repeatedly isolated. Linezolid MIC was > 32 mu g/ml by broth microdilution and > 16 mu g/ml by Etest.
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