Journal
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
Volume 32, Issue -, Pages S219-S222Publisher
SPRINGER INDIA
DOI: 10.1007/s12288-014-0478-x
Keywords
Good's syndrome; Myasthenia gravis; Pure red cell aplasia; Rituximab; Response; Thymoma
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Thymomas are often associated with a variety of autoimmune diseases, mostly myasthenia gravis. The association of thymomas with both pure red cell aplasia (PRCA) and Good's syndrome is exceedingly rare. To the best of our knowledge, the combination of a thymoma with manifestations of myasthenia gravis, PRCA, and Good's syndrome, as in our case herein, has not been described before in the medical literature. We present a 90-year-old man initially diagnosed with an asymptomatic thymoma. Later, he developed generalized muscle weakness and was found to have severe anemia. He was diagnosed with PRCA, myasthenia gravis and Good's syndrome. He responded to rituximab with restoration of bone marrow erythroid maturation and stabilization of red blood cell counts.
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