Journal
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT
Volume 47, Issue 3, Pages 329-338Publisher
SPRINGER
DOI: 10.1007/s11627-011-9343-x
Keywords
Artemisinin; Trichome; ROS; Reactive oxygen species; Jasmonic acid; Salicylic acid; Abscisic acid; Gibberellic acid; Cytokinin
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Funding
- National Institutes of Health [2R15GM069562-03]
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Artemisinin is a highly effective sesquiterpene lactone therapeutic produced in the plant, Artemisia annua. Despite its efficacy against malaria and many other infectious diseases and neoplasms, the drug is in short supply mainly because the plant produces low levels of the compound. This review updates the current understanding of artemisinin biosynthesis with a special focus on the emerging knowledge of how biosynthesis of the compound is regulated in planta.
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