Journal
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
Volume 45, Issue 1-2, Pages 10-14Publisher
SPRINGER
DOI: 10.1007/s11626-008-9145-6
Keywords
Tenascin-R; Neural stem/progenitor cells; Migration; Distribution
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Funding
- National Natural Science Foundation of China [30670793]
- Natural Science Foundation of Jiang Su Province [BK2006150]
- International Coorperation Projects of Jiang Su Province [BZ2006050]
- Jiang Su Province and Initial Fund of China Pharmaceutical University
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Extracellular matrix (ECM) molecules constitute a niche that modulates the migration, proliferation, and differentiation of neural stem/progenitor cells (NSPCs). The glycoprotein Tenascin-R (TN-R) is an ECM molecule, comprising multiple domains. Either the whole TN-R molecule or its distinct domains has been demonstrated to play a very important role in the developing central nervous system. However, little is known about the effect of the TN-R domain on NSPCs, especially NSPC migration. In the present study, we first show that both TN-R domains epidermal growth factor-like repeat (EGFL) and fibronectin type III (FN)6-8 can inhibit the NSPCs migration from neurospheres in vitro. Furthermore, both the EGFL and FN6-8 domains affect the distribution of neurons generated from neurospheres, indicating that EGFL and FN6-8 domains inhibit the motility of neurons generated from neurospheres. These results suggest that TN-R has an inhibitory effect on NSPCs migration.
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