Journal
IMMUNOTHERAPY
Volume 5, Issue 10, Pages 1075-1087Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/imt.13.102
Keywords
cancer; CCR2; CSF1R; macrophage; therapeutic
Categories
Funding
- Lustgarten Foundation
- V Foundation
- A Edward Mallinckrodt Jr Award
- Cancer Research Foundation
- Cancer Frontier Fund
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Tumor-associated macrophages are one of the major constituents of tumor stroma in many solid tumors and there is compelling preclinical and clinical evidence that macrophages promote cancer initiation and malignant progression. Therefore, these cells represent potential targets for therapeutic benefit. In this review, we will summarize macrophage phenotypic heterogeneity, the current understanding of how tumors take advantage of macrophage plasticity to generate immunosuppression, and how manipulation of specific macrophage populations can be used for therapeutic purposes through translational approaches.
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