Journal
IMMUNOTHERAPY
Volume 5, Issue 9, Pages 989-1004Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/imt.13.101
Keywords
differentiation; effector T cell; epigenetic effects; histone methyltranferase; memory cell maintenance
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Funding
- American Cancer Society
- Department of Defense
- NIH [R01-CA-172106-01]
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During immune responses, T cells require tightly controlled expression of transcriptional programs to regulate the balance between beneficial and harmful immunity. These transcriptional programs are critical for the lineage specification of effector T cells, the production of effector cytokines and molecules, and the development and maintenance of memory T cells. An emerging theme is that post-translational modification of histones by methylation plays an important role in orchestrating the expression of transcriptional programs in T cells. In this article, we provide a broad overview of histone methylation signatures for effector molecules and transcription factors in T cells, and the functional importance of histone methyltransferases in regulating T-cell immune responses.
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