Journal
IMMUNOTHERAPY
Volume 5, Issue 10, Pages 1055-1073Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/imt.13.103
Keywords
apoptotic cells; arthritis; cell therapy; dendritic cells; immunotherapy; inflammation; macrophages; tolerance; transplantation; Tregs
Categories
Funding
- INSERM
- EFS
- Universite of Franche-Comte
- Agence Nationale de la Recherche (LabEX LipSTIC) [ANR-11-LABX-0021]
- Agence Nationale de la Recherche (ECell France consortium) [ANR-11-INBS-0005]
- Ligue Contre le Cancer
- Etablissement Francais du Sang [2011-05]
- Arthritis Foundation Courtin
- Conseil Regional de Franche-Comte ('soutien au LabEX LipSTIC')
- Fondation pour la Recherche Medicale 'espoirs de la recherche'
- Agence Nationale de la Recherche (ANR) [ANR-11-INBS-0005] Funding Source: Agence Nationale de la Recherche (ANR)
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Apoptotic cell removal or interactions of early-stage apoptotic cells with immune cells are associated with an immunomodulatory microenvironment that can be harnessed to exert therapeutic effects. While the involved immune mechanisms are still being deciphered, apoptotic cell infusion has been tested in different experimental models where inflammation is deregulated. This includes chronic and acute inflammatory disorders such as arthritis, contact hypersensitivity and acute myocardial infarction. Apoptotic cell infusion has also been used in transplantation settings to prevent or treat acute and chronic rejection, as well as to limit acute graft-versus-host disease associated with allogeneic hematopoietic cell transplantation. Here, we review the mechanisms involved in apoptotic cell-induced immunomodulation and data obtained in preclinical models of transplantation and inflammatory diseases.
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