Journal
IMMUNOTHERAPY
Volume 4, Issue 5, Pages 549-554Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/IMT.12.42
Keywords
bevacizumab-213; bismuth; PC3 xenografts; prostate cancer; targeted alpha-radioimmunotherapy
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Funding
- USDOD
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Aim: To investigate orthotopic targeted alpha-radioimmunotherapy for the control of early-stage PC3 prostate cancer nude mouse xenografts using the radiolabeled bevacizumab (BZ) immunoconjugate (Bi-213-BZ), which emits short-range alpha-radiation. Materials & methods: 10(6) PC3 human prostate cancer cells were injected into the lower capsule of the mouse prostate gland 1 week prior to alpha-radioimmunotherapy. Mice were euthanized and assessed for tumour growth at 2 (two mice), 4 (two mice) and 6 weeks (three mice) post-therapy. The no-therapy control mice received a saline injection in equal volume to each BZ administration. Results: Bi-213-BZ is significantly more efficacious in inhibiting xenograft progression in the prostate gland compared with BZ alone (p = 0.009) and when compared with the 'no therapy' protocol (p < 0.0001). Conclusion: Orthotopic administration of Bi-213-BZ greatly improves the early control of organ-confined prostate cancer compared with BZ alone (p < 0.01).
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