Journal
IMMUNOTHERAPY
Volume 3, Issue 3, Pages 435-441Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/IMT.10.111
Keywords
autoimmune disease; autoreactive CD4(+) T cell; IFN-gamma; T-bet; Th1 cell
Categories
Funding
- NIH [NS-52177, 2G12RR013646-11]
- National Multiple Sclerosis Society [RG3499, RG3701]
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T-bet was initially described as a T-box transcription factor with an essential role in orchestrating Th1 cell differentiation. Subsequently, it was determined that T-bet controls the expression of numerous cytokines and their receptors, adhesion molecules and chemokine receptors, and therefore determines the differentiation and development status of many types of immune cells. The critical role of T-bet in autoimmune diseases, particularly multiple sclerosis and its animal model experimental autoimmune encephalomyelitis, implicates it as a potential biomarker for pathogenic T cells as well as a therapeutic drug target.
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