Journal
IMMUNOTHERAPY
Volume 3, Issue 10, Pages 1185-1202Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/IMT.11.116
Keywords
cancer-related inflammation; chemokines; HIV-1; macrophages; Mycobacterium tuberculosis; parasites infections; polarized inflammation; Tie2-expressing monocytes; tumor-associated macrophages
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Funding
- Associazione Italiana Ricerca sul Cancro (AIRC), Italy
- Fondazione Cariplo, Italy
- Ministero Universita Ricerca (MUR), Italy
- Ministero della Salute
- Regione Piemonte [331]
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Macrophages are crucial orchestrators of host defence and tissue homeostasis. Macrophages are heterogeneous and plastic cells that in response to different microenvironmental signals can mount a broad spectrum of different programs of polarized activation. In different pathological contexts including cancer and infectious diseases, macrophages diversity and plasticity may act as a double-edged sword. The elucidation of the molecular mechanisms underlying macrophages recruitment and functional activation allows the identification of valuable targets for the development of innovative therapeutic approaches.
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