Journal
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
Volume 32, Issue 2, Pages 228-237Publisher
INFORMA HEALTHCARE
DOI: 10.3109/08923970903296136
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Funding
- International Cooperative Biodiversity [U01 TW006634]
- Ledger Benbough Foundation
- NIH/NIGMS Institutional Research and Academic Career Development Award (IRACDA)
- FOGARTY INTERNATIONAL CENTER [U01TW006634] Funding Source: NIH RePORTER
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Natural products, secondary metabolites, isolated from plants, animals and microbes are important sources for bioactive molecules that in many cases have been developed into treatments for diseases. This review will focus on describing the potential for finding new treatments from marine natural products for inflammation, cancer, infections, and neurological disorders. Historically terrestrial natural products have been studied to a greater extent and such classic drugs as aspirin, vincristine and many of the antibiotics are derived from terrestrial natural products. The need for new therapeutics in the four areas mentioned is dire. Within the last 30 years marine natural products, with their unique structures and high level of halogenation, have shown many promising activities against the inflammatory response, cancer, infections and neurological disorders. The review will outline examples of such compounds and activities.
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