Journal
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
Volume 32, Issue 1, Pages 51-55Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/08923970903120997
Keywords
Tanshinone IIA; liver injury; concanavalin A; cytokines
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Funding
- NSFC Dean's Research [30701138]
- Minzu University 985 fund [cun985-3-3]
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Materials and Methods: In this study, the protective effects of TSN was examined by enzyme-linked immunosorbent assay (ELISA) and histochemistry of several cytokines. Results: TSN is found to significantly reduce plasma alanin aminotransferase and aspartate amino transferase levels in mice with concanavalin A-induced immune-mediated liver injury. TSN increases T lymphocyte subset CD3+, CD4+ and CD8+ ratios. Also, TSN significantly reduces inflammatory cytokines, including interleukin-2, interleukin-4, interferon-gamma and tumor necrosis factor alpha, while elevates anti-inflammatory cytokine, interleukin-10. Conclusions: TSN may provide a potential drug candidate for liver injury therapeutics.
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