Journal
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
Volume 31, Issue 2, Pages 159-173Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08923970802332164
Keywords
Apoptosis; caspase; immunity; parasite; trypanosoma cruzi
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Funding
- Rio de Janeiro State Science Foundation (Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro, FAPERJ)
- UNICEF/UNDP/World Bank/WHO
- Brazilian National Research Council (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, CNPq)
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Caspases are cysteine aspartases acting either as initiators (caspases 8,9, and 10) or executioners (caspases 3,6, and 7) to induce programmed cell death by apoptosis. Parasite infections by certain intracellular protozoans increase host cell life span by targeting caspase activation. Conversely, caspase activation, followed by apoptosis of lymphocytes and other cells, prevents effective immune responses to chronic parasite infection. Here we discuss how pharmacological inhibition of caspases might affect the immunity to protozoan infections, by either blocking or delaying apoptosis.
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