Journal
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
Volume 30, Issue 4, Pages 771-782Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08923970802279183
Keywords
Polysaccharopeptide; Astragalus Polysaccharides; Complex Prescription; Immunoregulatory Activity; Anti-Tumor Effects
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Funding
- Chongqing Science FIX
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The aim of this study was to determine whether polysaccharopeptide (PSP) and Astragalus polysaccharides (APS) can be combined together as a new complex prescription (PSP+APS) for aiding adriamycin (AMD) chemotherapy. Ehrlich's ascites carcinoma (EAC) was used to establish a solid tumor model in Kunming mice. Immunocytochemical and immunohistochemical analysis were employed to detect the immunoregulatory and anti-tumor effects of EAC bearing mice after 30 days of administration with PSP and APS. PSP and PSP+APS could significantly increase the percentage of CD3(+) and CD4(+) T-lymphocytes, the ratio of CD4(+)/CD8(+), and the expression of IL-2/IL-2R in spleen and Bax in tumor tissue, but led to a diminution of Bcl-2 and CDK4 in tumor tissue compared with those of control group. In addition, PSP+APS could restore the immunological effects against AMD-induced immunosuppression, such as the subset of leukomonocyte, the expression of IL-2/IL-2R in the spleen, and the thymus index. These findings suggest that the immunomodulatory and anti-cancer effects of this new formula (PSP+APS) were better than those of PSP alone, and also could resist immunosuppression induced by AMD.
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