Journal
IMMUNOLOGY LETTERS
Volume 161, Issue 2, Pages 174-178Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2013.12.012
Keywords
Metabolism; T cell; Tolerance; Adipose tissue; Treg cell
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The interplay of the immune system with other aspects of physiology is one of the hottest topics of the recent literature. A crucial example is the influence of metabolic cues on immune responses. It is now well accepted that upon activation, T lymphocytes take on a metabolic profile profoundly distinct from that of their quiescent and anergic counterparts; in these sense, T cell metabolism is highly dynamic and has a serious impact on the ability of T cell to grow, activate and differentiate. Specific metabolic pathways provide energy and biosynthetic precursors able to support specific T cell functions, such as effector, regulatory and memory. Here, we review the main signaling pathways that control metabolism and how the metabolic phenotypes of T cell subtypes integrate with their specific function. (C) 2013 Elsevier B.V. All rights reserved.
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