Journal
IMMUNOLOGY LETTERS
Volume 158, Issue 1-2, Pages 143-150Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2013.12.017
Keywords
Red ginseng extracts; Cytokine; Inflammasome; Interleukin-1; Macrophages; AIM2
Categories
Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [NRF-2012R1A1A1001645]
- Rural Development Administration, Republic of Korea [PJ009069]
- Kangwon National University
- National Research Council of Science & Technology (NST), Republic of Korea [C34260] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [21A20132112253, 2012R1A1A1001645] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Korean red ginseng extract (RGE) is one of the most popular natural herbs modulating the immune system. Although the effects of RGE on immunity have been reported, its effects on inflammasomes, multi-protein complexes that activate caspase-1 to induce maturation of interleukin (IL)-1 beta, have not been studied yet. In this study, we elucidated the effect of RGE on inflammasome activation using mouse and human macrophages. In our results, RGE inhibited IL-1 beta maturation resulting from NLRP3 inflammasome activation in both in vitro and in vivo models. In addition, RGE strongly attenuated IL-1 beta p secretion as well as pathogen clearance via pyroptotic cell death by macrophages through inhibition of AIM2 inflammasome activation. Ginsenosides Rg1 and Rh3 were suggested as inhibitors of the inflammasome activation. Thus, we demonstrated that RGE inhibits both NLRP3 and AIM2 inflammasome activation, with predominant involvement of the AIM2 inflammasome. Crown Copyright (C) 2014 Published by Elsevier B.V. All rights reserved.
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