Journal
IMMUNOLOGY LETTERS
Volume 155, Issue 1-2, Pages 21-23Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2013.09.027
Keywords
Allogeneic hematopoietic stem cell transplantation; Selective T-cell depletion; NK cell maturation; gamma delta(+) T cells
Categories
Funding
- AIRC (Associazione Italiana Ricerca sul Cancro)
- CNR (Consiglio Nazionale delle Ricerche)
- MIUR (Ministero dell'Istruzione, Universita e della Ricerca, Progetto Rilevante Interesse Nazionale)
- IRCCS Ospedale Pediatrico Bambino Gesu
Ask authors/readers for more resources
In recent years, infusion of T-cell depleted hematopoietic stem cells from an HLA-haploidentical relative has been shown to represent a suitable and effective, alternative option in patients in need of an allograft who lack an HLA-identical relative. In particular, this type of allograft is associated with the enormous advantage of offering an immediate transplant treatment to virtually all pediatric patients without an HLA-matched donor, whether related or unrelated, or a suitable umbilical cord blood unit. Several studies have shown that in patients given a T-cell depleted transplant relevant part of the anti-leukemia effect is mediated by alloreactive (i.e. KIR/HLA mismatched) Natural Killer cells originated from donor hematopoietic stem cells. After infusion of positively selected hematopoietic stem cell, fully functioning Natural Killer cells emerge in the recipient peripheral blood, persisting overtime, only several weeks after the allograft. We have developed a new method of T-cell depletion (based on the physical elimination of mature T cells carrying a and 13 chains of the T-cell receptor), which permits to maintain mature donor-derived alloreactive Natural Killer cells and gamma delta(+) T cells in the graft. We, thus, started a formal study in children with hematological disorders aimed at evaluating the safety and efficacy of this approach. Preliminary results on 60 children transplanted so far after this type of graft manipulation are particularly promising. (C) 2013 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available