Journal
IMMUNOLOGY LETTERS
Volume 149, Issue 1-2, Pages 9-18Publisher
ELSEVIER
DOI: 10.1016/j.imlet.2012.10.010
Keywords
Multiple sclerosis; Mesenchymal stem cells; Immunosuppression
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Funding
- Ministry of Health Care of Republic of Belarus [N20081618, N20112544]
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Mesenchymal stem cells (MSC) are promising for multiple sclerosis (MS) treatment. However, clinical results remain controversial, and no criteria are available for predicting the efficiency of MSC therapy. Using an in vitro model of lymphocytes and MSC cocultivation we revealed that the Index of MSC Suppression of myelin-induced memory T cells proliferation was stronger than that of PHA-stimulated proliferation and inversely correlated with patients' EDSS score. In vitro expression of CD119 (IFNGR1) in mitogen/myelin-stimulated T cells increased in the presence of MSC being inversely correlated with T-lymphocytes proliferation. The Index of MSC Suppression and CD119 expression in T-lymphocytes may be useful when assessing MSC immunosuppressive potential in MS patients. (C) 2012 Elsevier B.V. All rights reserved.
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