Journal
IMMUNOLOGY LETTERS
Volume 145, Issue 1-2, Pages 30-38Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2012.04.004
Keywords
Chemokines; Chemokine receptors; Scavenging receptors; Atypical receptors; Immunology
Categories
Funding
- European Union [LSHB-CT-2005-518167]
- MRC [G0802838, G9818340]
- MRC Centre for Immune Regulation
- Gottfried und Julia Bangerter-Rhyner-Stiftung, Basel
- Helmut Horten Foundation
- Italian Association for Cancer Research (AIRC)
- Regione Lombardia
- Fondazione Cariplo
- Ministero dell'Universita e della Ricerca
- MRC [G0802838, G0901113, G9818340] Funding Source: UKRI
- Medical Research Council [G0901113, G9818340, G0802838] Funding Source: researchfish
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A subset of chemokine receptors, initially called silent on the basis of their apparent failure to activate conventional signalling events, has recently attracted growing interest due to their ability to internalize, degrade, or transport ligands and thus modify gradients and create functional chemokine patterns in tissues. These receptors recognize distinct and complementary sets of ligands with high affinity, are strategically expressed in different cellular contexts, and lack structural determinants supporting Got; activation, a key signalling event in cell migration. This is in keeping with the hypothesis that they have evolved to fulfil fundamentally different functions to the classical signalling chemokine receptors. Based on these considerations, these receptors (D6, Duffy antigen receptor for chemokines (DARC), CCX-CKR1 and CXCR7) are now collectively considered as an emerging class of 'atypical' chemokine receptors. In this article, we review the biochemistry and biology of this emerging chemokine receptor subfamily. (C) 2012 Elsevier B.V. All rights reserved.
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