Journal
IMMUNOLOGY LETTERS
Volume 142, Issue 1-2, Pages 78-82Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2011.11.001
Keywords
B7-H1; Soluble; T cell; Dendritic cell; Coregulatory; Tumor cell
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Funding
- NCI NIH HHS [R01 CA134345] Funding Source: Medline
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Tumor cells aberrantly express several T cell inhibitory molecules including members of the B7-H coregulatory family. Presumably tumor-expressed B7-H1 and B7-H3 confer resistance to elimination by the immune system. In addition, elevated levels of soluble B7-H1 (sB7-H1) has been identified in the sera of cancer patients, including renal carcinoma patients and is associated with increased cancer related death. Here we report that sB7-H1 is produced and released by activated mature dendritic cells (mDC). Immature DC, macrophages, monocytes, or T cells are refractory to releasing sB7-H1. Exposure of CD4+ and CD8+ T cells to mDC-derived sB7-H1 molecules induced apoptosis. These data suggest that the immunobiology of B7-H1 is perhaps more complex than previously thought. sB7-H1 molecules may represent an unanticipated contributing factor to immune homeostasis. That both immune and tumor cells can be sources of sB7-H1 suggests that optimization of co-regulatory blockade immunotherapy for solid malignancies of necessity will require impact of targeting tumor and immune-derived B7-H1 molecules. (C) 2011 Elsevier B.V. All rights reserved.
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