Journal
IMMUNOLOGY LETTERS
Volume 136, Issue 2, Pages 115-121Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2010.11.001
Keywords
Rheumatoid arthritis; Natural Killer cell; Inflammation; Autoimmunity
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Funding
- MRC [G0900160] Funding Source: UKRI
- Medical Research Council [G0900160] Funding Source: researchfish
- Medical Research Council [G0900160] Funding Source: Medline
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Natural Killer (NK) cells are lymphocytes of the innate immune system, originally described by their capacity to control tumour cells and eliminate virus-infected cells. However accumulating evidence suggests that NK cells can interact with various components of the immune system and play a critical role in autoimmune diseases by limiting or exacerbating immune responses. Rheumatoid arthritis is a chronic inflammatory disease characterised by joint inflammation and cartilage and bone destruction. NK cells are enriched within the joints of patients with rheumatoid arthritis but how they contribute to disease pathology is currently not fully elucidated. This review will outline the current understanding of NK cell biology and how these cells may modulate disease pathogenesis in rheumatoid arthritis through interactions with other immune cells. (C) 2010 Elsevier B.V. All rights reserved.
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