Journal
IMMUNOLOGY LETTERS
Volume 128, Issue 1, Pages 46-50Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2009.11.003
Keywords
T cells; Suppression; Dendritic cells; VSIG4
Categories
Funding
- Nomarch Foundation for Excellent Talents of Science and Technology in Guizhou Province [(2005)230, (2009)31]
- Foundation of Guizhou Provincial Science and Technology Department [(2009)22211]
- National Natural Science Foundation of China [30772048]
- Natural Science Foundation of Chongqing [CSTC 2006BB5066]
- Clinical Innovative Foundation of Southwest Hospital [SWH2006A003]
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VSIG4 has been recently described as a B7 family-related protein. The immunotherapeutic potential of dendritic cells (DCs) transfected with VSIG4 recombinant adenovirus has not been characterized. In the present study, DCs were transfected with human VSIG4 (hVSIG4) recombinant adenovirus, a novel costimulatory molecule known to be a potent inhibitor of T cell activation. Transfected DCs were cocultured with allogeneic T cells and proliferation, cytokine production and T cell activation marker expression were assessed. The results showed that T cell proliferation potential, cytokine production and activation marker expression were suppressed after coculture with hVSIG4 recombinant adenovirus-transfected DCs. These findings suggest that DCs transfected with hVSIG4 recombinant adenovirus are capable of inducing allogeneic T cell suppression, which represents an ideal strategy for manipulating the immune response to transplanation or autoimmune diseases. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
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