Journal
IMMUNOLOGY LETTERS
Volume 127, Issue 1, Pages 8-12Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.imlet.2009.08.003
Keywords
Gamma delta lymphocytes; Inflammation; IL-17
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Funding
- French Ministere de I'Enseignement Superieur et de la Recherche
- Institut National de a Sante et de la Recherche Medicale (INSERM)
- Universite de Nantes
- Agence Nationale de la Recherche [A05118GS]
- Association pour la Recherche Sur le Cancer [3662, 4953]
- Institut National du Cancer [V9V2TER]
- Commission of the European Union Program [LSHP-CT-2003-503367]
- Cancer Immunotherapy [E06005NP/EEA06004GNP]
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Recent studies suggest that gamma delta T cells are innate IL-17 producers owing to unique features of their developmental program. A key contribution of this subset to T helper 17 responses has been also suggested by numerous physiopathological studies mainly performed in mouse models. In the present review, we will summarize the main features of IL-17-producing gamma delta T cells and highlight the similarities and differences between murine gamma delta T cells and their human counterparts. (C) 2009 Elsevier B.V. All rights reserved.
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